Lionel Messi and Cristiano Ronaldo first played against each other on April 23, 2008, during a UEFA Champions League semi-final match between FC Barcelona and Manchester United. The match took place at the Camp Nou in Barcelona, Spain.

In this highly anticipated clash, both Messi and Ronaldo were already recognized as two of the brightest talents in world football, though neither had reached the peak of their legendary careers yet. The game ended in a 0-0 draw, with both players showing glimpses of their extraordinary skills. Ronaldo had a chance to score early on but missed a penalty, while Messi, despite his dribbling prowess, couldn't break through Manchester United's defense.

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